Anti-NGF Local Therapy for Autonomic Dysreflexia in Spinal Cord Cord Injury

XWH - 11 - 1 - 0763 TITLE : Anti - NGF Local Therapy for Autonomic Dysreflexia in Spinal Cord Injury

Neutralizing intraspinal nerve growth factor blocks autonomic dysreflexia caused by spinal cord injury.

Autonomic dysreflexia is a condition that develops after spinal cord injury in which potentially life-threatening episodic hypertension is triggered by stimulation of sensory nerves in the body below the site of injury. Central sprouting of small-diameter primary afferent fibers in the dorsal horn of the spinal cord occurs concurrently with the development of this condition. We propose a model ...

Acute Severe Autonomic Dysreflexia during Spinal Cord Intramedullary Tumor Resectione

Background & Importance: Acute autonomic system impairment can be dangerous and life-threatening, and a clinician should be aware of its occurrence possibility. According to the anatomy of this system, spinal cord lesions could disturb its function. There are many reports of autonomic dysreflexia in spinal cord i njuries especially spinal cord trauma. Case Presentation: A 28 year-o...

بررسی اتونومیک دیس رفلکسی (Autonomic Dysreflexia) در۵۰ مورد از بیماران ضایعه نخاعی

ABSTRACT: Autonomic dysreflexia is a syndrome describing sympathetic overactivity occuring in patients with spinal cord lesions. This study is based on the determination of epidemiology , predisposing factors and relation of this syndrome to severity and level of the spinal cord lesion. Fifty spinal cord injured patients were studied retrospectively in Gilan province,in Center of Spinal Cord ...

Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia.

Severe spinal cord injuries above mid-thoracic levels can lead to a potentially life-threatening hypertensive condition termed autonomic dysreflexia, which is often triggered by painful distension of pelvic viscera (bladder or bowel) and consequent sensory fiber activation, including nociceptive C-fibers. Interruption of tonically active medullo-spinal pathways after injury causes disinhibition...